Endocrine Abstracts

The article presents a case of permanent central diabetes insipidus (CDI) in a patient after severe traumatic brain injury (TBI) in traffic accident. A 16-year-old boy entered to a medical facility in the coma (6 points of Glasgow Coma scale (GCS)). Diagnosis: acute TBI; severe cerebral contusion; subarachnoid hemorrhage; depressed comminuted cranial vault fracture; basilar skull fracture; visceral contusion. CDI diagnosed three days after injury when polyuria and hypernatremi...

Presented case demonstrates a rare diencephalic pathology — adipsic diabetes insipidus (ADI) with severe hypernatremia in a 58-year-old woman after ttranssphenoidal removal of stalk intraventricular craniopharyngioma. ADI was diagnosed because of hypernatremia (150–155 mmol/l), polyuria (up to 4 liters per day) and absence of thirst. Normalization of wa- ter-electrolyte balance occurred on the background of desmopressin therapy and sufficient hydration in postoperati...

Gonadotropinomas secreting biologically active hormones, most commonly follicle-stimulating hormone (FSH), are a very rare pathology. The clinical manifestations depend on the gender and age of the patient. Men may observe enlarged testicles and erectile dysfunction. Reports on the results of the drug treatment are sporadic.Objective: To describe a rare clinical case of an active giant FSH-secreting pituitary tumour in a 62-year-old man with the developm...

Reset osmostat syndrome (ROS) is characterized by a change of normal plasma osmolality level (decrease or increase), which leads to chronic dysnatremia (hypo- or hypernatremia). We have described a Clinical case of ROS and chronic hyponatremia in a patient with chordoid glioma of the III ventricle. It is known that the patient had previously been diagnosed with hyponatremia (131-134 mmol/l). She has not hypothyroidism and hypocorticism. There is normal filtration function of t...

Objective: To analyze the remission factors of surgical treatment of acromegaly Methods: A retrospective study involving 227 patients with acromegaly: 143 (63%) women and 84 (37%) men were operated via trassphenoidal endoscopic approach for pituitary adenoma removal between the periods of 2018-2021. The average age was 45 years [36.00, 56.00]. 118 patients had 6 months follow-up period (3-40 months). The IGF-1 index used for the evaluation, which was cal...